Short-term sensory plasticity as an endophenotype for schizophrenia

The purpose of this study is to investigate differences in brain connectivity between healthy control subjects and patients with schizophrenia. This will be done by testing if three different ways of stimulating the visual parts of the brain differ between healthy controls and patients with schizophrenia. Electrical brainwave activity will be recorded from the scalps of healthy control participants and patients with schizophrenia. These recordings, known as electroencephalography (EEG) are non-invasive and painless. The recordings will be taken while participants sit in a comfortable chair and look at a computer monitor that will display several different types of visual images for 2 minutes at a time. The images will be checkerboard patterns, circles and patterns of moving dots. furthermore, the participant will listen to tones while watching a movie on silence. Lastly, we will show a on a screen a woman talking, and while adding extra noise see how got the participant is in figuring out what the woman said. The resulting EEG brainwaves are then analyzed using a computer and the outputs of the analysis are compared between patients and controls. The study aims to obtain a sensitive measure of differences in brain connectivity between healthy controls and patients with schizophrenia. A better understanding of this could allow for the development of improved drug treatments for patients with schizophrenia, improved classification of schizophrenia subtypes and earlier diagnosis of schizophrenia.

This project is a collaboration with Dr. Edmund Lalor from the University of Rochester.

A flyer for the study can be found here: 

For more information, contact Douwe Horsthuis at

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